Screening and Profiling
West bioscience offers screening and profiling in following drug discovery areas.
Acetyltransferase Screening and Profiling
GCN5,P300
Bromodomain Screening and Profiling
ATAD2A, BRD2 (BD1 + BD2),BRD4 (BD1 + BD2),CREBBP, ATAD2B,BRD3 (BD1), BRD9 (BD1), SMARCA2, BAZ2B, BRD3 (BD2), BRDT (BD1),TAF1 (BD2), BRD1, BRD3(BD1 + BD2), BRG1, TAF1 (BD1 + BD2), BRD2 (BD1), BRD4 (BD1), BRPF3, TAF1L (BD2), BRD2 (BD2), BRD4 (BD2), CECR2, TAF1L (BD1 + BD2), TRIM24(TIF1)
Cell Surface Receptor Screening
BTLA, CD28, CTLA4, IDO-1, PD-1, PD-L1, PD-L2, PCSK9
DNA Methyltransferase Screening and Profiling
DNMT1, DNMT3A, DNMT3B/DNMT3L
HDAC Screening and Profiling
HDAC 1, HDAC 4, HDAC 7, HDAC 10, HDAC 2, HDAC 5, HDAC 8, HDAC 11, HDAC 3, HDAC 6, HDAC 9
Histone Demethylase Screening and Profiling
FBXL10 (KDM2B), FBXL11 (KDM2A), JARID1A (KDM5A), JARID1B (KDM5B), JARID1C (KDM5C), JHMD1D (KDM7), JMJD1A (KDM3A), JMJD2A (KDM4A), JMJD2B (KDM4B), JMJD2C (KDM4C), JMJD2D (KDM4D), JMJD2E (KDM4DL), JMJD3 (KDM6B) and LSD1 (KDM1A)
Histone Methyltransferase Screening and Profiling
EZH1, EZH2, EZH2 (Y641C), EZH2 (Y641F), EZH2 (Y641H), EZH2 (Y641N), EZH2 (Y641S), G9a, GLP, MLL1 Complex, NSD1, NSD2, PRMT1, PRMT3, PRMT4(CARM1), PRMT5, PRMT6, PRMT8, SETDB1, SET2, SET7/9, SET8, SUV39H1, SMYD2, SUV39H2, and SUV4-20H1
HSP90 Screening
HSP90α (C-terminal), HSP90α (N-terminal), HSP90β (C-terminal), HSP90β (N-terminal)
Immunotherapy Screening
BTLA, CD28, CTLA4, IDO-1, PD-1, PD-L1, PD-L2
Kinase Screening and Profiling
ALK, EGFR (T790M), Her2, BRAF, EGFR (L858R, T790M), Her4, BRAF (V600E), EGFR (murine), Lck, BTK, FAK, Jak2, c-Src, FGFR2, Jak3, CDK4/CyclinD3, FYN, SYK, EGFR (WT), GSK3a, VEGFR2/KDR, EGFR (L858R), GSK3b
Metabolic Enzymes Screening and Profiling
ACC1, Acetyl Coenzyme A carboxylase 1, IDH1(R132H), Isocitrate Dehydrogenase 1 (R132H), ACC2, Acetyl Coenzyme A carboxylase 2, IDH2 Isocitrate Dehydrogenase 2, ALOX-15, Arachidonate 15-lipoxygenase, IDH2(R140Q), Isocitrate Dehydrogenase 2 (R140Q), ACLY, ATP Citrate Lyase, MTAP, Methylthioadenosine phosphorylase, CA1, Carbonic Anhydrase 1, NAMPT, Nicotinamide phosphoribosyltransferase, CA2, Carbonic Anhydrase 2, NMNAT, Nicotinamide nucleotide adenylyltransferase 1, FUK, Fucokinase, PKL, Pyruvate kinase, Liver, FDH, Formaldehyde dehydrogenase, PKR, Pyruvate kinase, RBC, GK1, Galactokinase, PKM1, Pyruvate kinase M1, IDH1, Isocitrate Dehydrogenase 1, PKM2, Pyruvate kinase M2
Methyl-lysine Reader Screening and Profiling
PARP Screening and Profiling
PARP1 PARP5A (TNKS1), PARP7, PARP11, PARP15, PARP2, PARP5B (TNKS2), PARP8, PARP12, PARP3, PARP6, PARP10, PARP14
PDE Screening and Profiling
PDE1A, PDE4A4B, PDE6C, PDE1B, PDE4B1, PDE7A, PDE1C, PDE4B2, PDE7B, PDE2A1, PDE4C1, PDE8A1, PDE3A, PDE4D2, PDE9A2, PDE3B, PDE4D3, PDE10A1, PDE4A10, PDE4D7, PDE10A2, PDE4A1A, PDE5A, PDE11A
Protease Screening and Profiling
Cathepsin B, Caspase-3, DPP3, A20, HCV1a (D168V), Cathepsin F, Caspase-6, DPP4, Ataxin-3, HCV1b, Cathepsin L, Caspase-7, DPP7, OTUD6Bc, HCV1b (D168V), Cathepsin S, Caspase-8, DPP8, UCHL1, HCV1b (R155K), Cathepsin V, DPP9, UCHL3, HCV1b (R155Q), FAP, USP2, HCV2a, POP, USP5, MME, USP7, MMP1, USP8, MMP2, USP10, MMP9 (Q279R), USP14, Protein C-activated, Renin-activated
PTP Screening and Profiling
CD45/PTPRC,Bas, DEP1/PTPRJ, MEG-1, LAR/PTPRF, MEG-2, PTPIA2//PTPRN, PEST, RPTPβ/PTPRB, PRL-1(2-173), RPTPμ/PTPRM, PRL-2(2-167), RPTPγ/PTPRG, PRL-3(2-173), RPTPσ/PTPRS, PTP-D2/PTPN14, PTP1B(1-321)/PTPN1, PTP1B(1-321)/PTPN1, PTP1B(1-321)/PTPN1, PTP1B (full length), PTPMT1, SHP-1, SHP-2, STYXL1, TC-PTP
Pyruvate Kinase Screening
human and murine PKM2, PKLR Var1 (PKR), PKLR Var2 (PKL), and PKM2 Var2 (PKM1)
Sirtuin Screening and Profiling
Sirtuin 1, Sirtuin 2, Sirtuin 3, Sirtuin 5